Carbidopa/levodopa pharmacy errors in Parkinson's disease
Identifieur interne : 000789 ( Main/Exploration ); précédent : 000788; suivant : 000790Carbidopa/levodopa pharmacy errors in Parkinson's disease
Auteurs : Nasim R. Khadem [États-Unis] ; Melissa J. Nirenberg [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-12-15.
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Abstract
Outpatient pharmacy errors are common, but little is known about their occurrence in Parkinson's disease (PD). We prospectively studied carbidopa/levodopa pharmacy errors in a cohort of PD outpatients. Over 1 year, pharmacy errors occurred in 8/73 (11%) subjects treated with this medication, producing adverse drug events (ADEs) in 7/8 (87.5%) and increased healthcare utilization in 6/8 (75%) cases. The most common errors were substitution of controlled‐release for immediate‐release carbidopa/levodopa 25/100 mg (5/8; 62.5%) or dispensation of the wrong carbidopa/levodopa dosage (2/8; 25%). All errors involved ongoing prescriptions, including three interpharmacy transfers. Three subjects (37.5%) questioned pharmacy staff about the change in appearance of the tablets, but the error was corrected in only 1/3 of these cases. Carbidopa/levodopa outpatient pharmacy errors are a common, preventable cause of morbidity and excessive healthcare utilization in PD. Education of healthcare providers, patients, and pharmacy staff is warranted to reduce these errors and associated ADEs. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23311
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